![]() ![]() Predicting drug disposition via application of BCS: Transport/ absorption/ elimination interplay and development of a biopharmaceutics drug disposition classification system. Least-Square Fitting Analysis using Henderson-Hasselbalch equation for amphoteric compound was insufficient to describe ofloxacin solubility process in a series of pH.ġ. This mean that there was a salting in phenomena. Ofloxacin solubility in various ionic strengths showed that stronger ionic strength solution caused an increase in ofloxacin solubility. Changing the solution pH from 6.2 to 1.5 or to 12.5 affected the solubility of ofloxacin increased about 9.96 and 8.64 times higher, respectively. However, the solubility decreased at pH’s between pKa1 and pKa2. ![]() Results showed that ofloxacin solubility increased at pH’s below the pKa1 value (6.08) and above the pKa2 value (8.25). Solubility experiments were carried out using shaking thermostatic-waterbath for 3 hours at a temperature of 37☌ ± 1☌. Ofloxacin solubilities were measured at various pH ranged from 1.5 to 12.5 and ionic strengths from 0.01 to 0.20 respectively. The objectives of this research was to investigate the effects of pH and ionic strength on solubility profile of ofloxacin. ![]() Ofloxacin solubility is dependent on pH of the solvent due to its amphoteric properties. Ofloxacin is an antibiotic and categorized as class 2 in Biopharmaceutics Classification System (BCS).
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